Moving Beyond Angiotensin II to Also Target Aldosterone?
نویسندگان
چکیده
منابع مشابه
Beyond the Circulating Renin–Angiotensin Aldosterone System
The activation of the classical renin–angiotensin aldosterone system (RAAS) is known to be involved in the regulation of blood volume and blood pressure and plays an important role in cardiovascular pathology including hypertension and heart failure. Evidence is now available that independently of the classical RAAS, several RAAS components are expressed in cells from different organs including...
متن کاملCentral interactions of aldosterone and angiotensin II in aldosterone- and angiotensin II-induced hypertension.
Many studies have implicated both angiotensin II (ANG II) and aldosterone (Aldo) in the pathogenesis of hypertension, the progression of renal injury, and cardiac remodeling after myocardial infarction. In several cases, ANG II and Aldo have been shown to have synergistic interactions in the periphery. In the present studies, we tested the hypothesis that ANG II and Aldo interact centrally in A...
متن کاملStimulation of Aldosterone Secretion by Angiotensin II
The role of the renin-angiotensin system in renal hypertension has been investigated for many years but the relationship of the renin-angiotensin system to adrenocortical function has received less attention. In 1951, Deane and Masson,4 using the rat as an experimental animal, reported that encapsulation of the kidney, a procedure which results in hypertension presumably through release of reni...
متن کاملDopamine selectively inhibits aldosterone responses to angiotensin II in man.
Previous studies have demonstrated that dopamine inhibits the aldosterone response to angiotensin II in the sodium deplete state in man, but not in the normal sodium balance state. In this study we investigated nine normal male volunteers in balance at 10 mEq sodium intake to determine whether the inhibitory effect of dopamine is selective for angiotensin II-induced aldosterone secretion or als...
متن کاملDopamine Selectively Inhibits Aldosterone Responses to Angiotensin II in Humans
Previous studies have suggested that dopamine may have an important role as an inhibitor of aldosterone secretion in humans. Recent studies have also suggested that the adrenergic nervous system may have an important role in controlling aldosterone secretion. The present study investigated the effects of dopamine on aldosterone secretion in response to angiotensin II, with and without pretreatm...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2009
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2009.03.064